Spheroid models

Patient-Derived Spheroid Models

These patient-derived spheroid models are generated directly from patient biopsy samples and mimic the in vivo microenvironment. The scaffold-free system enables the spheroids to grow in 3D, leading to the formation of complex cellular structures and interactions that closely resemble the native tissue. This results in more biologically relevant data compared to 2D cell culture models, which are limited in their ability to mimic the in vivo microenvironment.

In addition, spheroids grown using the scaffold-free system are more resistant to genetic and epigenetic drift, which is often observed in long-term 2D cell culture models. The improved accuracy of spheroid models allows for a better prediction of drug efficacy in a patient population and can be used to determine personalized treatment options.

Overall, the use of patient-derived spheroid models in drug development offers a more accurate and relevant assessment of drug efficacy, leading to improved patient outcomes and reduced development costs.