Profile immune cell populations within the tumor microenvironment to understand immune response.
Assess T-cell receptor diversity and clonality, providing insights into immune recognition of cancer.
Measure immune response to cancer therapies, such as checkpoint inhibitors.
Evaluate functional activity of immune cells, such as cytotoxicity and cytokine production, to assess immunotherapy efficacy.
Samples:
Tumor biopsies.
Blood samples.
Primary immune cells.
Assays:
TCR profiling:
Analyzes T-cell receptor diversity and clonality using DNA or RNA from immune cells.
Gene expression profiling:
Measures the expression levels of immune-related genes using RNA extracted from immune cells or tissues.
IHC:
Visualizes immune cell infiltration and protein expression in tissue sections.
Flow cytometry:
Analyzes immune cell populations and their functional states using single-cell suspensions from blood or tissues.
Immune cell functional assays:
Assesses cytotoxicity, cytokine production, and other functional aspects of immune cells using cultured immune cells.
Contract research organization, which provides solutions for pharma and diagnostics companies, including consulting, cancer models development, and various assays for drug development.
